DRB1 alleles in Egyptian children with idiopathic Nephrotic Syndrome

ABSTRACT

Idiopathic nephrotic syndrome [INS] of children has been reported to be associated with serologically detected HLA-DR antigens. To investigate the association of INS and genes, 22 patients with INS and 20 control subjects were typed for HLA DRB1 during reverse hybridization technique. The study have found that the frequency of children positive for DRB1*03 alleles was significantly increased among patients with INS. The frequency of DRB1 01* alleles was also increased; however it was not significant. The frequency of DRB1*11 alleles was low in INS patients, but it was not significant when corrected to the number of antigens tested. These findings suggested that DRB1*03 genes, or closely associated unknown genes confer susceptibility to INS. The DEB1*03 genes are not involved in the response of INS patients to steroid therapy. The protective effect of DRB1*11 genes remains to be elucidated due small number of patients