Early endothelial dysfunction in insulin dependent diabetics

ABSTRACT

This study included 60 insulin-dependent diabetic patients. They were classified into 3 groups [each 20 patients]. The first group included patients without microangiopathy, the second included patients with early microangiopathy and the third included patients with late microangiopathy. 20 healthy subjects were chosen as controls. The results indicated that vWF was significantly increased in diabetics without evidence of microangiopathy [normal urinary albumin excretion, no retinopathy and neuropathy] compared to control and in patients with microangiopathy compared to those without. Also, a positive correlation between vWF and systolic blood pressure and urinary albumin excretion was found, but no correlation as regards age, sex and blood sugar at time of blood sampling was found