Genetic and dental study in patients with ectodermal dysplasia

ABSTRACT

Thirteen patients suffering from ectodermal dysplasia presented to the Pediatric Dentistry Department for dental rehabilitation. They were subjected to clinical genetic examination, pedigree construction, dental clinical and radiographic evaluation and dermatoglyphic study. Different modes of inheritance were evident in this study including autosomal dominant, autosomal recessive and X-linked inheritance. Rapp Hodgkin and ectrodactyly clefting syndrome [both associated with ED] were found among the group. Dental clinical examination and panoramic X-ray films revealed a mean of 12.8 missing teeth in the ED group. Upper central incisors, canines and first molars were the most stable tooth types. Asymmetry in absent teeth was present in all tooth types. Dermatoglyphic study in ED patients showed a wide variation when compared with a normal group of individuals. Almost all the parameters studied recorded a significant difference