Growth hormone [GH] insulin like growth factor-1 [IGF-1] axis in children with controlled IDDM

ABSTRACT

To study the growth hormone-insulin like growth factor-1 [GH- IGF-I] axis in children with IDDM who had fair to good metabolic control, 20 seven prepubertal and pubertal patients having HbA1c less than 10% were investigated in addition to 30 healthy nondiabetic subjects of matched age and sex served as a control group. All subjects were evaluated clinically with thorough anthropometric measurements. In conclusion, patients with IDDM with fair to good metabolic control showed normal growth parameters and normal GH-IGF-I axis with heightened GH release in response to stress