role of CA15.3 in cancer breast and its correlation with some other tumour markers

ABSTRACT

The aim of this study was to evaluate serum tumor markers [CA15-3, CEA and TNF] and ER receptors in serum and urine. It was done on 20 patients with breast cancer, 20 patients with benign breast lesions and 20 normal controls. A significant high level of the mean serum value of CA15-3 in cancer patients compared with benign and control groups. The mean preoperative levels returned nearly to normal in completely cured cases, while it was in a high level if there was metastasis or recurrence. In conclusion, serum CA15-3 and CEA levels could be valuable as a prognostic parameter and may have a role in monitoring patients with breast cancer. Other tested tumor markers, especially TNF may be complementary in this regard, while receptor patterns were important for determining the modality and response of treatment