Evaluation of cytokeratin fragment 19 [cyfra 21-1] as a tumour marker in lung cancer diagnosis

ABSTRACT

In this study, CYFRA 21-1 was measured in 60 patients with lung cancer and 30 patients presenting with nonmalignant diseases and compared it with tissue polypeptide antigen [TPA] and carcinoembryonic antigen [CEA]. Sensitivities of CYFRA 21-1, TPA and CEA in bronchogenic carcinoma were 73.3%, 66.6% and 53.3'70, respectively. The sensitivity of CYFRA 21-1 was significantly higher in the detection of NSCLC than that of TPA and CEA, while the sensitivities of TPA and CEA were higher than that of CYFRA 21-1 in the detection of SCLC. Sensitivity of CYFRA 21-1 and TPA was significantly higher than that of CEA in the detection of small tumors