Studies on neurologic functional and structural changes in acrylamide toxicity [an experimental study]

ABSTRACT

This work was designed to study the toxic effects of acrylamide and glycidamide in vivo on the isolated Sprague Dawley rats to compare the toxic effects of acrylamide versus its epoxide metabolite, glycidamide on the peripheral nerves. Acrylamide toxicity was induced by a daily i.p. injection of 25 and 50 mg/kg body weight/day, respectively, for 8 days. The weight of the rats, performances of the rotarod test and hind limb splay was performed every other day. On the 9th day, the animals were sacrificed and sciatic nerves were removed and examined. The results are presented and described