study on the relationship between thyroid hormones and adenosine deaminase enzyme activity in patients with auto- immune hyperthyroid disease

ABSTRACT

Adenosine deaminase ADA catalyzes the deamination of adenosine in purine metabolism. Adenosine deaminase deficiency is an inborn error resulting in immunodeficiency condition. Clinical interest in this enzyme has been revived by the discovery of a syndrome of severe humoral and cellular immunodeficiency associated with deficiency of ADA in somatic erythrocyte cell. The aim of present study is conducted to find the relationship between human hyperthyroid activities and immune etiology in graves disease. Forty individuals with hyperthyroidism autoimmune state were included in this study in comparison with forty normal persons. Thyroid hormones levels were estimated by HPLC and serum ADA specific activity was estimated using spctrophotometric method at 265 nm. Serum protein value was determined by Bradford method. Serum ADA activity was measured for 40 hyperthyroid patients as well as 40 normal individuals. The mean activity of ADA in patients was higher than in the controls. A significant increase in T3/T4 ratio and level of TSH were noticed. A positive correlation between thyroid level and ADA enzyme activity was noticed