Antimicrobial resistant pattern of staphylococcus aureus strains isolated from pediatric patients in Jordan

ABSTRACT

Development of resistance to antimicrobial agents by staphylococci is a major public health problem. Therefore, a retrospective study was conducted to determine the rate of resistance to antibiotics by S. aureus strains isolated from pediatric patients. A total of 472 different clinical specimens of pediatric patients were investigated. A high resistance of 96.7%, to aztreonam followed by 95.2% to imipenem, and 85.8% to cephalexin by Staphylococcus aureus strains was recorded. Low resistance rate was also recorded for vancomycin [1.4%] followed by cephalothin [9%],clindamycin [153%],tobramycin [15.7%],amikacin [18.1%] and ciprofloxacin [18.6%]. Aztreonam, imipenem, and most of [beta-lactam antibiotics were found to be ineffective at in vitro inhibition of the S. aureus of pediatric origin. S. aureus infections could be effectively treated with vancomycin, cephalothin, clindamycin, tobramycin, amikacin and ciprofloxacin. The high resistance rate to most of beta-lactam antibiotics studied could be attributed to their prevailing usage and abuse in the area of study