[Study and evaluation the influence of HPMC combination with different polymers in ketoprofen controlled release matrix tablets]

ABSTRACT

The controlled release of the drug is performed by trying to achieve to zero order kinetic mechanism from the dosage form. Zero-order kinetic mechanism means that drug release is separated from amount of the drug in a delivery system [the rate of released drug is constant during the time]. HPMC is Hydrophilic swellable polymer and widely used to control the release of drugs from matrix formulations, the release of drugs from their matrices depends on percentage of polymer in the matrices and its viscosity. In this study we investigate the applicability of HPMC combination with different polymers [PEG6000, Sodium alginate, Xanthan gum and PVA] for controlling the release of ketoprofen from matrix tablets. In drug release profiles, an initial rapid burst occurs in the first hour for matrices that consist of HPMC, then the release decrease during the time, it is not a suitable for Zero-order kinetic mechanism, but the initial rapid burst did not occur in the first hour for matrices that consist of HPMC combination with different polymers or HPMC polymers with various viscosities. The release during the time differs according to the type of studied polymer and the percentage of the two polymers and viscosity of the interested HPMC within the matrix. The kinetics of ketoprofen release was analyzed using different drug release models [zero order, first order, Higuchi, Korsmeyer and Peppas, Hixon and crowel], Zero order and Korsmeyer and Peppas equations were suitable for most of dissolution data from matrix tablets [0.95< R[2] <0.99]. The value of correlation factor R[2] according to zero order increases in combinations comparison to formulas that consist of HPMC alone