Antidiabetic activity of aqueous leaves extract of Sesbania sesban [L] Merr. in streptozotocin induced diabetic rats

The aqueous leaves extract of Sesbania sesban [L] Merr. [Family: Fabaceae] was evaluated for its antidiabetic potential on normal and streptozotocin [STZ]-induced diabetic rats. In the chronic model, the aqueous extract was administered to normal and STZ- induced diabetic rats at the doses of 250 and 500 mg/kg body weight [b.w.] p.o. per day for 30 days. The fasting Blood Glucose Levels [BGL], serum insulin level and biochemical data such as glycosylated hemoglobin, Total Cholesterol [TC], Triglycerides [TG], High Density Lipoproteins[HDL] and Low Density Lipoproteins [LDL] were evaluated and all were compared to that of the known anti-diabetic drug glibenclamide [0.25 mg/kg b.w.]. The statistical data indicated significant increase in the body weight, liver glycogen, serum insulin and HDL levels and decrease in blood glucose, glycosylated hemoglobin, total cholesterol and serum triglycerides when compared with glibenclamide. Thus the aqueous leaves extract of Sesbania sesban had beneficial effects in reducing the elevated blood glucose level and lipid profile of STZ-induced diabetic rats