Lack of association between interleukin 12 C[-1188]A polymorphism and irritable bowel syndrome
AJMB-Avicenna Journal of Medical Biotechnology. 2011; 3 (1): 45-48
in English
| IMEMR
| ID: emr-109410
ABSTRACT
Irritable Bowel Syndrome [IBS] is a functional gastrointestinal disorder, characterized by recurrent abdominal pain and altered bowel habits. This study was performed to investigate the important role of interleukin-12 [IL-12] in intestinal inflammation. For this study seventy one patients with IBS and 140 controls were investigated. The allele and genotype frequencies of IL-12 C[-1188]A were determined using polymerase chain reaction with sequence-specific primers. The allele A was more common that the allele C in both groups of patients and controls. There was not any significant difference on IL-12 alleles and genotypes between patients and controls. The AA genotype was the most common genotypes, which was seen in 57.4% of the patients and 51.4% of the controls [p=0.53]. Although frequency of the CC genotype in the control group was lower than the patient group, this difference was not significant [5.7% vs. 11.5%, respectively, p=0.16]. Considering the lack of association between IL-12 C[-1188]A polymorphism and IBS, this cytokine gene polymorphism may not have significant role in the pathophysiology of disease
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Polymorphism, Genetic
/
Polymerase Chain Reaction
/
Interleukin-12
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
Avicenna J. Med. Biotechnol.
Year:
2011
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