Genetic association analysis of dopamine DRD3 Ser9Gly polymorphism and schizophrenia in Malay population

ABSTRACT

Molecular components of the dopamine receptor [DRD3] play an important role in the pathophysiology of schizophrenia [SCZ]. Previous studies have demonstrated an association between the DRD3 Ser9Gly polymorphism and SCZ but the results have been inconclusive. In this study, we investigated this controversial association between the Ser9Gly [A/G] polymorphism and SCZ using Malay cases-control [261 cases/157 controls] samples. PCR-RFLP was performed to genotype the distribution of the DRD3 Ser9Gly polymorphism. Both healthy control and SCHZ patient groups were in of Hardy-Weinberg equilibrium for the analyzed genetic variability. There was a significant association between the genotype distribution DRD3 polymorphisms and SCZ [chi[2]= 9.359; df= 2; P= 0.009]. We believe that further studies are required to examine the association between others dopamine-related genes and the behavioral phenotypes of SCZ