[Allele frequency of 12 microsatellites in chromosome 8, 11, 12 and 16 in Tehran lipid and glucose study]

ABSTRACT

Most linkage and population genetic studies that use microsatellites assume that the polymorphism observed at these loci is due simply to variation in the number of units of a single repeat. These variations guide us in the study of the genetic patterns of some disease. This study reports the allele frequency of 12 microsatellites in Tehranians. Five hundred and ninety-one subjects with an average age of 39 +/- 19 years, with and without metabolic syndrome, were selected for investigation of the allele frequency of 12 microsatellites, the D8S1132, D8S1779, D8S514, D8S1743, D11S1998, D11S1304, D11S934, D12S96, D12S1632, D12S329, D16S2624 and D16S3096 using and fragment analysis technique. There are different repeats in the chromosomes studied. Chromosome 8 10-26.2bp repeats; chromosome 11 8.1-35bp; chromosome 12 2-32bp and chromosome 16 9.2-28bp. The most hetrozygote marker is D8S1132 and the least is D12S96. The most significant findings of this study is reporting allele frequency of some Short Tandem Repeats for the first time in Tehran. In this study some new alleles were found in Iranian subjects, the presence of which may be a tool for genetic association studies in the future