Comparison between immediate and delayed imaging after gadolinium chelate injection for detecting enhanced lesions in multiple sclerosis
Iranian Journal of Radiology. 2010; 7 (4): 235-239
in En
| IMEMR
| ID: emr-109997
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ABSTRACT
Magnetic resonance imaging [MRI] is a noninvasive and valuable method in the diagnosis of Multiple Sclerosis [MS]. Compared with other modalities, the sensitivity of MRI for detection of the lesion increases using magnetization transfer [MT] and delayed imaging. Our aim was to compare the two methods in detecting MS lesions. In this double-blind clinical trial, twenty-one patients with the definite diagnosis of MS referred to Poursina Hospital, Rasht were included. Two radiologists evaluated all the images. First, images without contrast were conducted, then 0.1 mmol/kg contrast material [Dotarem, single dose] was injected and after 30 minutes, T1W and MT images were obtained. Seventy-two hours later, T1W images were obtained immediately after injection of 0.2 mmol/kg contrast material [double dose]. The data were analyzed using Fisher's and McNemar tests by SPSS for Windows. Delayed magnetization transfer showed 44 enhanced lesions using MT [69.84%] and 29 lesions using T1 [46.03%]. In addition, the number of enhanced lesions in the delayed method were significantly more than those in the immediate method [p value=0.003]. The use of single dose in combination with MT and delayed images after 20-30 minutes enables us to detect more enhanced lesions
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Index:
IMEMR
Main subject:
Magnetic Resonance Imaging
/
Image Enhancement
/
Chelating Agents
/
Double-Blind Method
/
Reproducibility of Results
/
Sensitivity and Specificity
/
Contrast Media
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Multiple Sclerosis
Type of study:
Clinical_trials
Limits:
Humans
Language:
En
Journal:
Iran. J. Radiol.
Year:
2010