Synthesis of certain 1,3,4oxadiazoles, 1,2,4-triazoles and 1,3,4-thiadiazoles as potential chemotherapeutic agents

ABSTRACT

A series of five membered heterocycles namely 5-substituted-4-acetyl-2-[2-chloro-4 nitrophenyl]- 1,3,4-oxadiazolines 6-10, 4-substituted aminomethyl-2-[2-chloro-4-nitrophenyl]-1,3,4-oxadiazoline-5-thiones 12-15, 2-substituted-5-[2-chloro-4-nitrophenyl]-1,3,4-oxadiazoles 22-27, 4-substituted-3-[2-chloro-4-nitrophenyl]-5-phenyl-1,2,4-triazoles 28-30 and 2-substituted amino-5-[2-chloro-4-nitro-phenyl]-1,3,4-thiadiazoles 36-40, were synthesized. Eight representative compounds were tested for their invitro antimicrobial activity against some pathogenic microorganisms, some of them were proved to be active