[Enhancing the dissolution rate of felodipine by mechanical activation]

ABSTRACT

This research aimed to study the effect of mechanical activation [Slugging and Milling "SM"] on the physiochemical properties of the Felodipine with hydrophilic polymer was studied. Two types of PhysicalMixtures [PM] was prepared The first one was physical mixture of Felodipine with poly ethylene glycol [PEG6000] and / or surfactant which is poloxamer [POL], and the second one was physical mixture of Felodipine with poly vinyl pyrolidine [PVP] and / or surfactant which is poloxamer. Then slugging and milling [SM] was made for each mixture. To know the effect of SM on the physiochemical properties of the previous prepared mixture, a comparison between each mixture before and after SM was made, by using differential scanning calorimetry [DSC], Fourier Transmission Infrared [FTIR] and X-ray diffractometry. The effect of [SM] on the mechanochemistry of each material was studied by comparison the DSC scan for each material alone before and after SM. Finally the physical interaction between polymer [PEG or PVP] and surfactant [POL] was studied. The result of DSC showed that is a physical interaction between polymer and Felodipine in case of SM, but this interaction were absent in case of the physical mixture. The result of DSC also showed the effect of SM on the mechanochemistry of the used material. The result of FTIR showed a hydrophilic interaction between Felodipine and polymer in case of SM and also showed a significant interaction between polymer [PVP] and surfactant [POL]. Finally the result of X-ray showed that Felodipine remains in his crystal form after SM