[Evaluation of biochemical effects of a pharmaceutical formulation [cream] based essential oils extracted from Marrubium vulgaris cons. against osteoarticular disorders, rheumatoid arthritis and musculoskeletal disorders [MSDs]]

ABSTRACT

In many cases medical therapy [prescription anti-inflammatory drugs and corticosteroids] does not provide solutions to serious suffering of patients caused by the various joint diseases, or it has side effects exacerbating the situation. It is granted that medicinal plants are able to treat simple illnesses such as cold, or to avert more important as the ulcer. In this work, we study the effect of therapy on the natural articular deficits. We develop an approach that uses medicinal creams [dosage formulation] enriched concentration plant extracts [essential oils]. The concentrated active ingredients have been applied at the joint through the skin. In this study we are interested in a plant called Marrubium bulgaris. We studied the biochemical effects of essential oils in subjects with osteoarticular disorders Rheumatoid arthritis [65 +/- 5 years, n10], TMS musicians [35 +/- 6 years, n=10], as an cream of olive oil 3 xj and for 3 weeks with a placebo group that receives a cream without active ingredients. Our results indicate the corrective effects of the essential oils of bone resorption and cartilage. The application of these treatments was inversely associated with risk of osteoarticular, subjects applying these creams have marked the values of pyridinoline in its various forms, and alkaline phosphatase, CRP less important than before the treatment compared to placebo group [0.60 <4<0.90 p<0.05]. Through the power of the tested active ingredients that contain essential oils of this plant, we found that our treatments are effective where other drugs and surgery have failed