[Comparison of Hashimoto thyroiditis in patients with type 1 diabetes and controls]

ABSTRACT

Type 1 diabetes is the most common metabolic disease worldwide. Thyroid autoimmune diseases is the most common endocrinopathy in diabetes type 1. Therefore, assessment of thyroid function tests and anti thyroid antibodies in diabetic patients [type 1] is beneficial in early. The purpose of this study was to compare the anti-thyroid antibodies in diabetic children [type 1] with healthy children. In this descriptive-analytic study, 65 children with Type 1 diabetes and 65 healthy children who had referred to Children's Hospital in Qazvin were selected by simple sampling. Anti-TG, Anti-TPO, TSH and T4 were measured in both groups. Chi-square, t-independent and Kruskal Valis was used for statistical analysis. The difference between sex and age in both groups [case and control] was not significant but BMI percentile was significantly different. Positive Anti-TG was 10.8% in patients and was 1.5% in controls. The difference was statistically significant [p=0.029]. 16.9% of patients and 3.1% of controls had positive Anti-TPO [p=0.024]. 10.8% of patients had increased TSH and decreased T4 level [Overt Hypthyroidism]. 4.6% of controls had increased TSH and decreased T4 level [Subclinical Hypothyroidism]. The difference was statistically significant for T4. It seems that the prevalence of Hashimoto thyroiditis in patients with type 1 diabetes is more than healthy people. Hence, evaluation of thyroid function tests [TFT] and antithyroid antibodies [Anti-TPO] is necessary to diagnosis and treatment of autoimmune thyroid disorders