Effects of aluminum chloride on some hematological and biological parameters of white albino mice

ABSTRACT

Aluminum salts induced toxic effects in animal models, some of which involve alterations in enzymatic activities. Moreover, aluminum intoxication may induce anemia and encephalopathy in animals and humans. This work was conducted to study the effect of aluminum toxicity on some hematological and biochemical blood parameters in white Albino mice. A total of eighty "8-week-old" male white Albino mice, weighing about 35 g were divided into four equal groups. The control group and three groups received 50, 100 and 200 micro g/ liter of aluminum chloride for [24, 48 and 96] hours. The mice showed a physiological response after 24 hrs of administrated AlC13[50, 100] and 200 micro g/L, respectively with approximately 100% increase in red blood cells [RBCs], white blood cells [WBCs], hematocrit value [Hc] and hemoglobin content [Hb], respectively. Also, there are increased in serum glucose level, total protein, aspartate and alanine amino transferase activities [AST and ALT] and increased serum creatinine and uric acid concentration after 24hrs of 50, 100 and 200 micro g/liter of AlC 3, respectively. White albino mice given AlCAlC13 50, 100] and 200 micro g/L, respectively for 48 hrs increase blood constituents, serum glucose level, serum total protein and serum AST, ALT activities, creatinine and uric acid level. Also, white albino mice given 50, 100 and 200 micro g/L of aluminum chloride for 96 hrs presented that highly significant increased RBCs, WBCs, Hc and Hb as well as in the serum glucose level, serum total protein and serum AST and ALT activities. The serum creatinine and uric acid increased in mice given AlC13 [50, 100 and 200] micro g/L, respectively for 96 hrs. White albino mice responded to AlC 13 administered by increasing their WBCs, enzymes of liver functions and kidney functions