Initial presentation of acute lymphoblastic leukemia with osteoporosis and multiple spontaneous bone fractures
IRCMJ-Iranian Red Crescent Medical Journal. 2011; 13 (1): 52-54
in English
| IMEMR
| ID: emr-110850
ABSTRACT
Acute lymphoblastic leukemia [ALL] is the most common childhood malignancy. Skeletal abnormalities have been described in association with ALL including osteoprosis and bone fractures. Different factors including the disease itself or soluble products of malignant cells and treatment agents like cytotoxic drugs, methotroxate, corticosteroids and radiotherapy may be responsible for defective bone homeostasis in these patients. Orthopedic conditions and pain may be the first manifestation of acute leukemia and it is important for physicians to recognize the skeletal manifestation of acute childhood leukemia because of a delay in diagnosis has adverse effect on survival. We present a child with ALL that refer with multi bone fractures as a first manifestation of the disease
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Osteoporosis
/
Radiotherapy
/
Methotrexate
/
Adrenal Cortex Hormones
/
Fractures, Bone
Type of study:
Case report
Limits:
Humans
/
Male
Language:
English
Journal:
Iran. Red Crescent Med. J.
Year:
2011
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