Inhibition of 14C uptake by candida albicans: a new method for investigation of intracellular killing by phagocytes
Medical Journal of the Islamic Republic of Iran. 1988; 2 (3): 237-242
in English
| IMEMR
| ID: emr-11086
ABSTRACT
A radio assay employing 14 C-Urodone to measure the intracellular killing of Candida albicans by phagocytes is presented. The principle of this new method is that after killing of Candida albicans by phagocytes RNA synthesis stops and therefore uridine uptake is diminished whilst viable candida in cultures would take up uridine and as a result, high CPM counts can be obtained within 135 min. of incubation in test cultures. Leukocytes from 30 normal subjects showed reduced C.P.M. following killing of Candida albicans
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Phagocytes
/
Carbon Radioisotopes
Language:
English
Journal:
Med. J. Islamic Rep. Iran
Year:
1988
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