Pathological threat of developing resistance against broad spectrum antibiotics

ABSTRACT

The objectives of the study were to describe the recent sensitivity pattern against Escherichia coli and Staphylococcus aureus in relation to ciprofloxacin and cefepime as to maintain the effectiveness of the treatment regimen. Furthermore the resistance of these organisms was explored to estimate the impending burden of resistant infections. During the present study 50 isolates of Staphylococcus aureus and 50 isolates of Escherichia coli have been collected from Dr. Ziauddin Hospital Laboratory and Imam Clinic laboratory. The study was done in the department of Pharmaceuticals, Faculty of Pharmacy, Karachi University. The sensitivity pattern of these isolates to ciprofloxacin and cefepime was determined by using Disc Diffusion Method. Data was analyzed by using National Committee for Clinical laboratory Standard [NCCLS]. Data indicated that the clinical isolate of Eschericia coli has exhibited 58% sensitivity, 42% resistance to Cefepime. Where as Staphylococcus aureus has shown 54% sensitivity, 46% resistance to Cefepime. The clinical isolates of Eschericia coli has exhibited 36% sensitivity, 64% resistance to ciprofloxacin, where as Staphylococcus aureus, has shown 44% sensitivity, 56% resistance to Ciprofloxacin. The prescribed drugs must not be used frequently otherwise resistance threat against the relevant microorganism would be increased at an alarming level