Effect of variations in insulin on serum leptin levels in pre and post menopausal women

ABSTRACT

To measure the serum leptin and insulin levels and assess that how insulin affects these levels in pre and post menopausal obese and non-obese women. The experimental work was carried out at the department of Biochemistry and Molecular Biology and Center for Research in Experimental and Applied Medicine-1 [CREAM-1], Army Medical College, Rawalpindi and was spread on a duration of 18 months. The samples for the study were obtained from healthy 80 subjects and divided into premenopausal and postmenopausal groups of 40 each. The groups were further sub-divided into obese and non obese based on the body mass index [cut off BMI value=25 kg/m[2]]. There is significant difference in the mean age [p insulin [p triglyceride [p insulin [p leptin [p Leptin has significant positive correlation with weight, Insulin and HOMA IR whereas Insulin has significant positcve correlation with weight, leptin and HOMA IR. Menopause does not influence FSL levels. The variations observed in FSL levels between pre and postmenopausal women, in some studies, might be due to differences in their mean FSI levels. The mean FSL tends to increase with increased weight irrespective of menopausal status