Insulin resistance, liver enzymes and the metabolic syndrome
Medical Forum Monthly. 2009; 20 (6): 15-20
in English
| IMEMR
| ID: emr-111218
ABSTRACT
The objective of the study was to test the hypothesis that enzymes conventionally associated with liver dysfunction [alkaline phosphatase, aspartate aminotransferase, alanine arninotransferase] may predict diabetes. Three hundred type-2 diabetics were selected from Diabetic clinic and one hundred and fifty non-diabetes control from population. Biochemical testing of fasting and 2 hours serum insulin, renal, liver functions and protein was measured by using standard method and instruments. Insulin resistance was calculated using the homeostasis model assessment for insulin resistance [HOMA-IR] method. Statistical analysis of samples and control subjects were done by using SPSS-13. At baseline all three enzymes were related to most of the features of the metabolic syndrome. Serum alkaline phosphatase levels as well as serum transaminases also showed a statistical significant difference at P<0.05. The HOMA-IR in the type-2 diabetic group was significantly greater than that of the control group [mean +/- SD 3.84 +/- 2.3 vs. 1.62 +/- 0.79 units [P<0.05]. Serum total proteins and albumin significantly reduced in type-2 diabetic subjects. Mild elevations in liver enzymes and decreased levels in serum proteins are associated with features of the metabolic syndrome
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Aspartate Aminotransferases
/
Blood Glucose
/
Blood Proteins
/
Phosphoprotein Phosphatases
/
Metabolic Syndrome
/
Diabetes Mellitus, Type 2
/
Alanine Transaminase
/
Liver
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
Med. Forum Mon.
Year:
2009
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