Association of lipoprotein [a] with lipid disorders in offspring of patients with premature myocardial infarction

ABSTRACT

To investigate the association of Lipoprotein[a] with lipid disorders in offspring of patients with premature myocardial infarction. The study was carried out in Saidu Teaching Hospital and Biochemistiy Department of Saidu Medical College, Swat, from May to July 2007. Sixty children and youngsters were included. Thirty cases were those with fathers having myocardial infarction before the age of 55 years and thirty children matched for age, gender, dietary and smoking habits without a family history of coronary artery disease served as controls. Total cholesterol, triglycerides, high density lipoprotein cholesterol, low density lipoprotein cholesterol and Lipoprotein[a] were measured in children of both the groups. The serum level of Lipoprotein[a] was significantly higher in the cases as compared to controls proving a strong association between altered lipid levels and high lipoprotein[a] in the blood. Lipid disorders are common in offspring of patients with premature myocardial infarction and there is a strong association between altered lipid levels and high lipoprotein[a] in the blood of these persons