Protective role of zinc in piroxicam induced hepatic lobule damage in mice

ABSTRACT

To determine the effect of piroxicam in the hepatic lobule with protective role of zinc in mice and colorate the observation with serum enzyme level. An Experimental study. October 2008 to November 2008. Department of Anatomy, Basic Medical Sciences Institute, JPMC, Karachi. 30 adult mice [25-30gm] were divided into A, B and C groups. Group A served as a control, group B received piroxicam 0.3mg/kg body weight up, and group C received zinc 1mg/kg body weight lip and piroxicam as group B. After completion of study [i.e. 6 weeks] animals were scarified, blood sample was collected for serum enzyme level and their livers were removed and after processing, paraffin section were stained with H and E for the histological examination. U and E section of group A reveals normal histology of hepatic lobule, group B shows dilated central vein, irregular hepatic cord, distorted hepatocytes, dilated sinusoids and mononuclear infiltration, group C shows altered histological changes less then group B but more then group A Serum enzyme level [alkaline phosphatase] is within normal range in group A but significantly increase in group B and in group C less significantly increase as compare to group B but more then group A. Present study concludes that the therapeutic dose of piroxicam causes hepatic damage and zinc along with piroxicam is effective to prevent the hepatic injury