Glucose, insulin and adiponectin relationships in serum of type-2-Egyptian diabetic patients

ABSTRACT

Seventy six samples of blood were taken from 66 volunteers [38 male and 28 female] of type-2-diabetic patients and 10 samples from intact subjects. Serum samples were collected from the lab of French Teaching Hospital, Cairo, Egypt. The age of patients and control varied from 35 to 50 years. Serum glucose. insulin and adiponectin levels were measured at fasting and postprandial states. There were high serum glucose and insulin levels in diabetic patients comparing to control subjects. The serum adiponectin levels in all type-2-diabetic patients [10.57-15.47 micro g/ml] were significantly less than that present in control [23.35 micro g/ml]. Serum adiponectin level was significantly and negatively correlated with serum glucose. In male and female diabetic patients, the adiponectin levels varied from 13.45 to 15.05 micro g/ml and from 7.68 to 17.10 micro g/ml, respectively. A negatively significant correlation was present between serum insulin and adiponectin levels in male patients. At postprandial state, the glucose level was elevated with both insignificant increase in insulin level and decrease in adiponectin level. The data suggest that blood adiponectin must be determind and increased to the normal level by medicine before treatment of type-2-diabetic patients