new antidiabetic drug restoring normal insulin secretion from beta-cells and normal histology

ABSTRACT

A benzimidazole derivative was prepared and evaluated as antidiabetic drug. It was found to be nontoxic to albino mice up to dose of 3200 mg/kg body weight. It had no hypoglycemic activity but it was found to cause beta-cell regeneration in alloxanoised rats. Measuring blood glucose levels and insulin levels in treated alloxanoised rats were found to reach normal levels after treatment. In addition histological examination of the pancreas from treated alloxanoised rats showed normal islets of langerhans with normal morphology of beta-cells