Synthesis and anticancer activity of some acenaphtho [1,2-e] [1,2,4]-triazinotriazine derivatives

ABSTRACT

Some new fused heterobicydic nitrogen systems such as acenaphtho [1,2-e] [1,2,4] triazinotriazine derivatives 2-16 have been synthesized via heterocyclization reactions upon treatment of acenaphtho[1,2-e][1,2,4]triazin hydrazide [1] with bifunctional oxygen and halogen compounds. Structural assignment of the synthesized products 2-16 was confirmed by elemental analyses and spectral data [[1]H-NMR and [13]C-NMR determinations]. Some selected compounds were screened and showed remarkable anticancer activity