Incidence of SEN virus in polytransfused cases of chronic renal failure on maintenance haemodialysis

ABSTRACT

SENV is the latest viral agent that has been proposed as a cause of NANE hepatitis. It appears to be endemic throughout the world since it has been found in many countries, although with different incidence. The prevalence of SENV-D and SENV-H in polytransfused cases such as chronic renal failure on maintenance haemodialysis was significantly higher. This study was conducted on 75 subjects; 50 polytransfused cases of chronic renal failure on maintenance haemodialysis and 25 normal healthy subjects as a control. Blood samples were collected and PCR was performed for detection of SENV-D and SENV-H in patients group and control. SENV-H viraemia were detected in five patients out of fifty [10%]; one case was positive for SENV-H alone [2%] while four cases were coinfected of SENV-H with HCV [8%]. They were all negative for SENV-D. Neither SENV-D nor SENV-H was detected in control group. No significant difference in the severity of liver affection reflected by the mean transaminase [AST and ALT] levels was found between SENV positive and SENV negative patients group [P >0.05]