Some markers of oxidative stress and antioxidant status in patients with psoriasis

ABSTRACT

Psoriasis is a common, chronic inflammatory skin disease with unknown etiology. It has been suggested that increased reactive oxygen species [ROS] production and deficient function of antioxidant systems activities may be involved in the pathogenesis of the disease. The goal of this study was to determine the role of lipid peroxidation, assess the antioxidant activity in psoriasis patients and to correlate it with severity of the disease. In this study malondialdehyde [MDA], super oxide dismutase [SOD] enzyme activity, and total antioxidant oxidative capacity [AOC%], Vit E and beta carotene levels in 24 patients with psoriasis were investigated and compared with those of 12 control subjects. Clinical severity of the disease was determined according to the Psoriasis Area Severity Index [PASI] scores in patients. Our results showed that MDA as a marker of oxidative stress was significantly higher in psoriatic patients, while AOC%, SOD, Vit E and beta carotene as markers of antioxidant status were significantly lower in psoriatic patients compared to control. However, there was no correlation between PASI score and plasma AOC% and erythrocyte SOD levels. In conclusion our results may provide some evidence for the role of ROS production associated with decrease antioxidant potential in psoriasis