Modulation of some human mononuclear cells activities by procaine
Middle East Journal of Anesthesiology. 1988; 9 (5): 417-28
in English
| IMEMR
| ID: emr-11252
ABSTRACT
The in vitro effects of a local anesthetic, a membrane active drug, procaine, on some functional activities of circulating human lymphocytes and monocytes were studied. Procaine inhibited spontaneous E-rosette formation between T-lymphocytes and sheep erythrocytes and EAC-rosettes with B-lymphocytes. In addition, procaine inhibited both the phagocytosis of latex particles by normal monocytes and the proliferation of lymphocytes in an allogeneic mixed leukocyte culture. Morphologically the procaine-treated cells exhibited a relative increase in the size of the cytoplasmic rim around their nuclei. The results indicated that procaine might be considered as a non-specific immunoregulator, modulating to some extent the functional expression of human peripheral blood mononuclear cells activities
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Leukocytes, Mononuclear
Language:
English
Journal:
Middle East J. Anesthesiol.
Year:
1988
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