[ effect of reversible locus coeruleus [LC] on i.v self-administration of morphine and morphine withdrawal syndrome[MWS] signs in rats]
Journal of Zanjan University of Medical Sciences and Health Services. 2007; 15 (59): 9-19
in Persian
| IMEMR
| ID: emr-112613
ABSTRACT
Locus coeruleus [LC] has been hypothesized to play an important role in a variety of behaviors and opiate withdrawal. This study was designed to determine the effects of reversible inactivation of LC on self-administration of morphine and morphine- withdrawal syndrome signs [MWS]. 24 male rats [250-300gr] were surgically implanted bilaterally with cannula in LC then implanted with catheters in the right jugular vein. The rats were tested in 2 groupsControl[saline] and morphine. Morphine group was divided into 3 subgroups control, sham-operated and LC-inactivated group where they received 1microL 2% Lidocaine 5 minutes prior to testing. Animals were allowed to self-administer morphine [1mg/infusion] during 10 consecutive days for 2 hours. The number of lever pressing was recorded. At the end of the training day all groups received naloxone [2mg/kg I.P] and MWS were studied for 30 minutes. LC inactivation prevents the development of tolerance and dependence on morphine and greatly attenuates morphine-withdrawal syndrome. LC inactivation not only attenuates morphine withdrawal syndrome but also prevents morphine tolerance and dependence in rats
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Rats
/
Substance Withdrawal Syndrome
/
Self Administration
/
Injections, Intravenous
/
Morphine
/
Morphine Dependence
Limits:
Animals
Language:
Persian
Journal:
J. Zanjan Univ. Med. Sci. Health Serv.
Year:
2007
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