Lipid profiles in epileptic children treated with carbamazepine and valporic acid

ABSTRACT

Epilepsy in children often requires prolonged AED therapy. The aim of this study was to define the effect of treatment with some antiepileptic drugs Carbamazepine [CBZ] and Valporate [VPA] on serum lipid profiles alter nine months of therapy. This study was conducted on forty epileptic children, twenty five cases had generalized tonic - clonic and fifteen cases of partial seizures. There were control group [twenty healthy children] and patient group [forty children] the latter was classified randomly into two subgroups as follows [1] Carbamazepine subgroups twenty cases] and [2] Valporate subgroup [twenty cases]. Our results revealed that serum total cholesterol, LDL- cholesterol, HDL- cholesterol, triglycerides and VLDL-cholesterol levels were increased alter treatment with CBZ with a statistically significant difference compared to serum levels before treatment, on the other hand these serum lipids levels decreased in patients treated with VPA when compared to their serum levels before treatment with a statistically significant difference. Valporic acid has a favorable effect on serum lipid profile and it may be the preferable antiepileptic drug with regards to the effects of the medication on the lipid metabolism