role of RCC, vimentin and cytokeratin 7 in the differential diagnosis of conventional renal cell carcinoma

ABSTRACT

The present study investigates the value of RCC, Cytokeratin 7 and vimentin immunohistochemical staining in the distinction between granular variant of renal cell carcinoma, chromophobe renal cell carcinoma and oncocytoma. Chromophobe renal cell carcinomas were characterized by positive cytoplasmic immunoreactivity to CK7 [100%] while they were negative to vimentin, and RCC. Conventional renal cell carcinoma showed positive immunoreactivity to; vimentin [100%], RCC [73%], and CK7 [14%]. On the other hand, oncocytoma showed focal weak staining to RCC while they were negative to the other markers. A panel of antibodies including RCC, Cytokeratin 7, and vimentin is useful tool in differentiating chromophobe renal cell carcinoma from granular type renal cell carcinoma and oncocytoma