Accidental five fold overdose of propofol for induction in a 38-days-old infant undergoing emergency bilateral inguinal hernia repair

ABSTRACT

The induction dose of propofol is higher in younger children [2.9 mg/kg for infants younger than 2 years] than in older children [2.2 mg/kg for children 6-12 years of age]. A modest reduction in systolic blood pressure often accompanies bolus administration. The major concern with propofol is the potential for propofol infusion syndrome [lactic acidosis, rhabdomyolysis, cardiac and renal failure], which is generally associated with high-dose infusion for an extended period. We report a 38-days-old male infant underwent emergency bilateral inguinal hernia repair who accidentally received a five-fold dose of propofol for induction of general anesthesia