Malondialdehyde level in the cord blood of newborn infants

ABSTRACT

In this study, we aim to demonstrate that measurement of the malondialdehyde [MDA] level in the umbilical cord blood of newborn infants born via cesarean section [C/S] and normal vaginal delivery [NVD] is indicative of oxidative stress during the perinatal period. The study was conducted at Bakirkoy Training and Research Hospital between January 2006 and April 2006 on 15 newborns born via elective C/S, 15 newborns born via emergency C/S, and 15 newborns born via normal vaginal delivery. Complete blood count, total bilirubin, glucose, creatinine phosphokinase [CPK], uric acid, iron, blood gas, and malondialdehyde levels were measured in the umbilical cord blood. Malondialdehyde levels in the umbilical cord blood in the emergency C/S and NVD groups were found to be statistically and significantly higher than those in the elective C/S group. In the emergency C/S group, it was determined that the malondialdehyde level increased as the oxygen saturation of the umbilical cord blood increased. In the NVD group, a positive correlation was detected between the total bilirubin and malondialdehyde levels in the umbilical cord blood. In the emergency C/S group, the malondialdehyde level was recorded to be high in the infants with high level of uric acid in the umbilical cord blood. We concluded that the malondialdehyde level in umbilical cord blood could serve as an indication of perinatal oxidative stress and that it could thus help in preventing permanent damage