Pregnancy outcome in the luteal defective infertile women following ICSI, embryo transfer and luteal support therapy

ABSTRACT

Defects in the formation and function of the corpus luteum result in a reduction of progesterone secretion and inadequate secretory transformation of the endometerium. Luteal defective cycles are recognized in 50% of unovulatory patients and 60% of women with recurrent abortions. The goal of the present study was to study the outcome of ICSI in infertile women with mild and marked luteal defective cycles following embryo transfer. Patients and Methods: Women with mild and marked luteal defective cycles were undergone ovulation induction, oocyte retrieval, ICSI and embryo transfer program. Follicular fluid progesterone, estradiol, testosterone were measured. The pregnancy rates in both luteal defective cycles [LDC] were recorded. The concentration of estradiol and progesterone were significantly higher in the mild LDC compared to marked LDC. The concentration of prolactine and testosterone were significantly higher in the marked LDC than mild LDC. The concentrations of FSH and LH were not significantly different between both groups of LDC. The ICSI rate was 74.4% in the mild and 70.7% in the marked LDC. The embryo transfer rate was significantly higher in the mild LDC compared to the marked LDC group [85.2% versus 50% respectively, P<0.001]. The pregnancy rate per embryo transfer was 30.3% in the marked LDC compared to 38% in the mild LDC group. The patient cancellation rates were 13% and 4% in the marked and mild LDC groups. The application of ICSI and luteal support therapy improves embryo implantation and pregnancy rates in infertile women with mild and marked luteal defective cycles and in men with severe teratozoospermia and poor sperm penetration score