[Comparative study for the analytical performance of potassium clavulanate assay methods in the United States, British, and Japanese pharmacopoeias]

ABSTRACT

A comparative study was conducted to verify the performance parameters of the compendial methods utilized for the assay of potassium clavulanate in the United States [USP], British [BP], and Japanese [JP] pharmacopoeias. The aim of the study was to find out the degree of accordance between the methods in terms of accuracy, precision, and linearity in the range 50-150% of the sample solution concentration provided in the monograph. The stability-indicating power of each method was verified in order to determine their suitability for use in stability studies in addition to the approximate cost of each method: