CNS stimulant activity of Qurs saffron [a herbal medicine] in experimental animal models

ABSTRACT

To confirm the safety and efficacy of the product for human health due to its wide use and to explore its effects on CNS. Experimental and observational. This study was conducted at Frontier medical college Abbottabad Pakistan in March 2011. Thirty rabbits divided into five groups were administered Qurs saffron at the dose of 50, 100 and 200 mg/kg, Caffeine 100mg/kg orally and the last group was taken as control group, received normosaline. The animals were observed for behavioral changes at 30 min intervals. At 50mg/kg of the drug were found to have mild stimulant activity, while 100mg/kg were found to have a moderate CNS stimulant properties same like caffeine at a dose of 50mg/kg. While at a dose of 200mg/kg_Qurs saffron were found to have a strong stimulant properties. From the current study it can be concluded that the product have dose dependent CNS stimulant effects