Glucose-6-Phosphate dehydrogenase phenotypes in Bahrain: Quantitative analysis and electrophoretic characterization

ABSTRACT

To determine the prevalence of glucose-6-phosphate dehydrogenase [G6PD] deficiency and to define the phenotypes present in Bahrain. Quantitative determination of G6PD activity and electrophoretic characterization were done on cord blood samples collected from 100 Bahraini neonates. Severe G6PD deficiency was found in 29% of the study population. In 25 of those [18 males and 7 females], the enzyme activity was undetectable. When quantitative enzyme activity and electrophoretic mobility results were anlaysed six phenotypes of G6PD were identified