Clinical spectrum of adult onset spontaneous primary hypothyroidism

ABSTRACT

Hypothyroidism is a common entity in this part of the world. The objective of this study was to analyse the clinical and endocrine/biochemical data of 250 subjects with spontaneous primary hypothyroidism. Subjects 18 years or older who had thyroid stimulating hormone value of >10 mIU/ml were studied for clinical and biochemical features. There was a female predominance, female to male ratio being 3.2 1. There was a less frequent occurrence of thyromegaly and the patients were relatively younger. Predominant occurrence in females and less frequent occurrence of thyromegaly suggest a possible autoimmune atrophic thyroiditis as the most probable etiology of spontaneous primary hypothyroidism