Thiamin responsive anemia, report of 3 cases and review of the literature

ABSTRACT

Three cases of megaloblastic anemia in children with concurrent hyperglycemia and sensorineural deafness are described. Therapy with folic acid and vitamin B[12] had little effect. The anemia responded to thiamine administration [100 mg/day] within 14 days. The hyperglycemia of the youngest patient <3 yrs old resolved but not that of the oldest [6 yrs old]. It is believed that hyperglycemia and sensorineural deafness can be corrected in cases of thiamine-responsive megaloblastic anemia if therapy can be started at a younger age. In all three cases the parents were related