Some toxicological studies on croton oil in white rats

ABSTRACT

Eighty albino rats of both sexes were used in this study and divided into 4 equal groups. The first 3 groups were injected I/P with croton oil in a dose of 0.50 and 1.00 mg/k gm B. Wt. respectively while the 4th group was kept as control and injected 0.5 ml tween-80 I/P. Results revealed that R.B.Cs. count, HB% and PCV were decreased while W.B.Cs count were increased significantly. Differential leucocytic counts were significantly decreased in lymphocytes and significantly increased in neutrophils and monocytes while eosinophils were slightly increased but basophils were not affected. Levels of GOT, GPT and AP were significantly increased while T.P. albumin and globulin were significantly decreased in serum of toxicated rats. Urea and creatinine were decreased but potassium was increased in comparison to control group. Calcium and phosphorous levels were slightly changed in serum of treated rats. Microscopically the liver was congested with mononuclear aggregation and the hepatocyte suffered from degenerative changes. The kidney showed haemorrahages with haemosidrosis, mononuclear cell infilteration, congestive blood vessels with fibrinoid necrosis of their wall, the tubules showed degenerative changes and hyaline cast. The lung suffered from congetion with emphysema. The heart revealed haemorrahages with some hyalinization. The brain lesion was extravasated R.B.Cs. in meninges. Testicels showed few oedema in the intertubular spaces