Effect of bovine virus diarrhea on the immune response of Egyptian buffalo calves

ABSTRACT

Five buffalo calves were experimentally infected with Singer strain of bovine viral diarrhea virus [BVDV]. The haematological changes and immune response were investigated. Transient leucopenia followed by leucocytosis was recorded. BVD viral infection induced immunosuppresion which was demonstrated by monitoring phagocytic activity of peripheral blood monocytes and rosette formation of T-cells. The cell-mediated immune response was tested by the lymphocyte transformation test. Serum neutralization test was performed to determine the humoral response