Effect of chronic toxicity of Kat [catha edulis] extract on some physiological parameters of male rats
Journal of the Egyptian Society of Toxicology. 1994; 13 (2): 45-49
in English
| IMEMR
| ID: emr-116043
ABSTRACT
The effects of chronic administration of kat [Calha edulis] on several physiological and biochemical parameters of the male rats [Rattus norvegicus] were studied. Cholesterol and ascorbic acid contents of the adrenals were found to be gradually declined as a result of kat-administration. Neurotransmitters in the brain appeared to be affected by kat-administration. Norepinephrine content was significantly decreased and acetylcholine significantly increased in kat-treated than in control rats. However, no significant changes in serotonin level were found. Kat administration also affected the plasma testosterone level; an initial rise occurred during the first four months probably as a result of the stimulating effect of kat, then a general decrease was observed until the termination of the experiment. On the other hand, kat-treated rats appeared to have no significant changes in the urinary 17-ketosteroid level throughout the experiment
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Ascorbic Acid
/
Rats
/
Testosterone
/
Brain
/
Catecholamines
/
Cholesterol
/
17-Ketosteroids
Limits:
Animals
Language:
English
Journal:
J. Egypt. Soc. Toxicol.
Year:
1994
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