Audiosensitization and desensitization control seizure susceptibility in hamsters

ABSTRACT

This study demonstrates that a brief exposure [90 seconds] to sound of door bell at an intensity of 95 decibels during a critical period in development of hamster induces seizure susceptibility in a nonsusceptible strain. Repeated stimulation at specific intervals induced an anticonvulsant state against the spontaneous sizure in epileptic hamsters. The critical age of audiosensitivity was found to be from 28 to 31 days. The increase of the age with increase of the interval between stimulation and test was associated with a decrease in seizure susceptibility