Hepatocellular Carcinoma: a review of 140 cases
Annals of Saudi Medicine. 1996; 16 (1): 53-55
in English
| IMEMR
| ID: emr-116142
ABSTRACT
Saudi Arabia appears to have an unusually high incidence of hepatocellular carcinoma, which has been causally associated with a high prevalence of hepatitis B virus [HBV]. Other risk factors, including hepatitis C virus [HCV] infection are currently not known. A study was undertaken to establish the risk factors and clinicopathological features of hepatocellular carcinoma in Saudi Arabia. The profiles of 140 patients with a biopsy-proven hepatocellular carcinoma were analyzed. Demographic data revealed a strong male preponderance [malefemale = 5.71] and 114 patients [81.4%] were found to have or have had HBV infection. The data concerning HCV infection were incomplete, but suggest a causal association [nine of 33 patients]. An absence of alcohol as a risk factor was noteworthy. Clinical jaundice and right upper quadrant abdominal pain were the most frequent presenting features. Abnormal liver function tests were present in 125 patients [89.3%] at diagnosis and serum alpha fetoprotein was elevated in 112 patients [80%]. The majority of patients had locally advanced, inoperable disease and the prognosis was uniformly dismal. The median survival was 61 days
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Index:
IMEMR (Eastern Mediterranean)
Main subject:
Hepatitis B virus
/
Risk Factors
/
Hepatitis C
/
Liver
Language:
English
Journal:
Ann. Saudi Med.
Year:
1996
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