Quantitative and qualitative estimation of tissue eggs burden in bilharzial patients clinicopathological correiation

ABSTRACT

Bilharziasis is the most common endemic disease in Egypt. Sequlae of pathological lesions and their severity vary considerably. This paper will show the correlation between the intensity, of infestation with the species of ova to the production of pathology. Tissue digestion technique was used to examine 64 biopsy specimens which included two from bilharzial contracted bladders, 16 from bilharzial bladder ulcers, seven cystectomy specimens from bilharzial patients with bladder cancer, and 22 from. bilharzial ureteric strictures. Of the remaining specimens, nine were from uncomplicated bilharzial bladders and eight from simple uncomplicated bilharzial ureters. The pathological lesions were found to be due to a mixed infestation [haemotobium and mansoni] in 63.5% of the cases of ureteric strictures, 68% of chronic bladder ulcers and 100% of bilharzial contracted bladders. The infestation was due to haemotobium only in 100% of simple Bilharzial bladder cases and in 87.5% of uncomplicated ureters. Accordingly, strains of schistosoma mansoni are more productive of tissue reaction and fibrosis, which can offer [an explanation for the varied clinical picture in different people. Management of urinary tract bilharziasis should cover both haemotobium and mansoni strains